INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort Study: Design and Rationale for INSPPIRE 2 From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pan
- Tony Vines
- Mar 28, 2024
- 2 min read
Date: | November / December 2018 |
PMID: | |
Category: | 1 |
Authors: | Aliye Uc, Emily R Perito 1, John F Pohl 2, Uzma Shah 3, Maisam Abu-El-Haija 4, Bradley Barth 5, Melena D Bellin 6, Kate M Ellery 7, Douglas S Fishman 8, Cheryl E Gariepy 9, Matthew J Giefer 10, Tanja Gonska 11, Melvin B Heyman 1, Ryan W Himes 8, Sohail Z Husain 7, Asim Maqbool 12, Maria R Mascarenhas 12, Brian A McFerron 13, Veronique D Morinville 14, Tom K Lin 4, Quin Y Liu 15, Jaimie D Nathan 16, Sue J Rhee 1, Chee Y Ooi 17, Zachary M Sellers 18, Sarah Jane Schwarzenberg 6, Jose Serrano 19, David M Troendle 5, Steven L Werlin 20, Michael Wilschanski 21, Yuhua Zheng 22, Ying Yuan 23, Mark E Lowe 24; Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) |
Abstract: |
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We created the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE (INSPPIRE 2) cohort to study the risk factors, natural history, and outcomes of pediatric acute recurrent pancreatitis and chronic pancreatitis (CP). Patient and physician questionnaires collect information on demographics, clinical history, family and social history, and disease outcomes. Health-related quality of life, depression, and anxiety are measured using validated questionnaires. Information entered on paper questionnaires is transferred into a database managed by Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer's Coordinating and Data Management Center. Biosamples are collected for DNA isolation and analysis of most common pancreatitis-associated genes.Twenty-two sites (18 in the United States, 2 in Canada, and 1 each in Israel and Australia) are participating in the INSPPIRE 2 study. These sites have enrolled 211 subjects into the INSPPIRE 2 database toward our goal to recruit more than 800 patients in 2 years. The INSPPIRE 2 cohort study is an extension of the INSPPIRE cohort study with a larger and more diverse patient population. Our goals have expanded to include evaluating risk factors for CP, its sequelae, and psychosocial factors associated with pediatric acute recurrent pancreatitis and CP.
Acknowledgements:
The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute, the National Institute of Health, or the National Institute of Diabetes and Digestive and Kidney Diseases.
The Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) Research Consortia is supported and funded by grants from the National Cancer Institute and the National Institute of Diabetes and Digestive and Kidney Diseases under the following award numbers:
Project Number: | Awardee Organization |
U01DK108326 | Baylor College of Medicine |
U01DK108314 | Cedars-Sinai Medical Center |
U01DK108332 | Indiana University |
U01DK108323 | Kaiser Foundation Research Institute |
U01DK108288 | Mayo Clinic |
U01DK108327 | Ohio State University |
U01DK108300 | Stanford University |
U01DK108320 | University of Florida |
U01DK108306 | University of Pittsburgh |
U01DK108328 | University of Texas MD Anderson Cancer Center |
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